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IRC Tire SS540 Front 110/70-12 47L T10281

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Gut is a leading international journal in gastroenterology and hepatology and has an established reputation for publishing first class clinical research of the alimentary tract, the liver, biliary tree and pancreas. Gut delivers up-to-date, authoritative, clinically oriented coverage in all areas of gastroenterology and hepatology. Regular features include articles by leading authorities describing novel mechanisms of disease and new management strategies, both diagnostic and therapeutic, likely to impact on clinical practice within the foreseeable future.

Gut is an official journal of the British Society of Gastroenterology and has two companion titles: Frontline Gastroenterology for education and practice and BMJ Open Gastroenterology for sound science clinical research.

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Featured Video

Synergistic targeting and resistance to PARP inhibition in pancreatic cancer

To cite: Gout J, Perkhofer L, Morawe M, et al. Gut 2021;70:743-760.

Read the full article here: link
Objective: ATM serine/threonine kinase (ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), in pancreatic ductal adenocarcinoma (PDAC).

Conclusion: Analysis of the molecular susceptibilities triggered by ATM deficiency in PDAC allow elaboration of an efficient mutation-specific combinational therapeutic approach that can be also implemented in a genotype-independent manner by ATM inhibition.

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